Touré Yeya T, Oduola Ayoade M J, Morel Carlos M
Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, 20 Avenue Appia, CH-1211, Geneva 27, Switzerland.
Trends Parasitol. 2004 Mar;20(3):142-9. doi: 10.1016/j.pt.2004.01.008.
Malaria remains a major public health problem that is made worse by poor implementation of control measures, and by the spread of drug- and insecticide-resistant parasites and vectors, respectively. Availability of the Anopheles gambiae genome sequence will accelerate identification and exploitation of new target genes in this insect vector. This provides unique opportunities to improve on existing vector control tools and to generate new tools within a global partnership. However, significant capacity needs to be built for investigators in disease-endemic countries to exploit the genome data. When integrated with existing strategies, the new tools will form an effective package for selective vector control in an effort to prevent mortality and morbidity due to malaria.
疟疾仍然是一个重大的公共卫生问题，而控制措施实施不力以及耐药寄生虫和抗杀虫剂病媒的传播分别使这一问题更加恶化。冈比亚按蚊基因组序列的可得性将加速在这种昆虫病媒中鉴定和利用新的靶基因。这为改进现有的病媒控制工具以及在全球伙伴关系内开发新工具提供了独特机会。然而，需要为疾病流行国家的研究人员大力培养能力，以便利用基因组数据。如果与现有战略相结合，新工具将形成一套有效的选择性病媒控制方案，努力预防疟疾导致的死亡和发病。
