妇科恶性肿瘤的肠道和口腔微生物群：相互作用、机制和治疗价值。
Gut and oral microbiota in gynecological cancers: interaction, mechanism, and therapeutic value.
机构信息
Department of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China.
Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
出版信息
NPJ Biofilms Microbiomes. 2024 Oct 10;10(1):104. doi: 10.1038/s41522-024-00577-7.
Gynecologic cancers develop from the female reproductive organs. Microbial dysbiosis in the gut and oral cavity can communicate with each other through various ways, leading to mucosal destruction, inflammatory response, genomic instability, and ultimately inducing cancer and worsening. Here, we introduce the mechanisms of interactions between gut and oral microbiota and their changes in the development of gynecologic tumors. In addition, new therapeutic approaches based on microbiota modulation are discussed.
妇科癌症源自女性生殖器官。肠道和口腔中的微生物失调可以通过多种方式相互沟通，导致粘膜破坏、炎症反应、基因组不稳定，最终诱发癌症并使其恶化。在这里，我们介绍了肠道和口腔微生物群之间相互作用的机制及其在妇科肿瘤发展中的变化。此外，还讨论了基于微生物调节的新治疗方法。
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