Strähle Uwe, Lam Chen Sok, Ertzer Raymond, Rastegar Sepand
Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries, BP10142, 67404 Illkirch Cedex, France.
Trends Genet. 2004 Mar;20(3):155-62. doi: 10.1016/j.tig.2004.01.002.
Situated at the ventral-most part of the vertebrate neural tube, the floor plate (FP) is an important signalling centre that controls the regional differentiation of neurons in the nervous system. It secretes guidance molecules that direct ventrally navigating axons crucial for the correct wiring of neuronal circuits. Although the function of the FP is well-conserved from fish to humans, discrepancies exists with respect to both the signalling system involved in FP induction, and the origin of the FP in various vertebrate species. Recent findings from the embryos of zebrafish, chicken and mouse provide insights that reconcile previous results and suggest common themes in vertebrate FP specification.
底板（FP）位于脊椎动物神经管的最腹侧部分，是一个重要的信号中心，控制着神经系统中神经元的区域分化。它分泌引导分子，引导轴突向腹侧导航，这对于神经元回路的正确布线至关重要。尽管从鱼类到人类，FP的功能都得到了很好的保留，但在FP诱导所涉及的信号系统以及各种脊椎动物物种中FP的起源方面仍存在差异。斑马鱼、鸡和小鼠胚胎的最新研究结果提供了一些见解，这些见解调和了先前的结果，并揭示了脊椎动物FP特化中的共同主题。
