Chen Deyun, Hou Qian, Zhong Lingzhi, Zhao Yali, Li Meirong, Fu Xiaobing
Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, Beijing 100853, China.
Trauma Treatment Center, Central Laboratory, Chinese PLA General Hospital, Hainan Branch, 9 Haitang Bay, Sanya 572014, China.
Stem Cells Int. 2019 Dec 31;2019:6789823. doi: 10.1155/2019/6789823. eCollection 2019.
Skin regeneration is a vexing problem in the field of regenerative medicine. A bioactive molecule-based strategy has been frequently used in skin wound healing in recent years. Bioactive molecules are practical tools for regulating cellular processes and have been applied to control cellular differentiation, dedifferentiation, and reprogramming. In this review, we focus on recent progress in the use of bioactive molecules in skin regenerative medicine, by which desired cell types can be generated for cell therapy and conventional therapeutics can be developed to repair and regenerate skin through activation of the endogenous repairing potential. We further prospect that the bioactive molecule-base method might be one of the promising strategies to achieve skin regeneration in the future.
皮肤再生是再生医学领域一个棘手的问题。近年来，基于生物活性分子的策略已频繁用于皮肤伤口愈合。生物活性分子是调节细胞过程的实用工具，已被应用于控制细胞分化、去分化和重编程。在本综述中，我们重点关注生物活性分子在皮肤再生医学中的最新进展，通过这些进展可以生成用于细胞治疗的所需细胞类型，并通过激活内源性修复潜力来开发传统疗法以修复和再生皮肤。我们进一步展望，基于生物活性分子的方法可能是未来实现皮肤再生的有前景的策略之一。
