Devaney Eileen
Parasitology Group, Division of Veterinary Infection and Immunity, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK.
Int J Parasitol. 2006 May 31;36(6):641-9. doi: 10.1016/j.ijpara.2006.02.006. Epub 2006 Mar 13.
An unanswered question in the biology of many parasites is the mechanism by which environmental (or external) and intrinsic signals are integrated to determine the switch from one developmental stage to the next. This is particularly pertinent for nematode parasites, many of which have a free-living stage in the environment prior to infection of the mammalian host, or for parasites such as filarial nematodes, which utilise an insect vector for transmission. The environmental changes experienced by a parasite upon infection of a mammalian host are extremely complex and poorly understood. However, the ability of a parasite to sense its new environment must be intrinsically linked to its developmental programme, as progression of the life cycle is dependent upon the infection event. In this review, the relationship between temperature and development in filarial nematodes and in the free-living species Caenorhabditis elegans is summarised, with a focus on the role of heat shock factor and heat shock protein 90 in the nematode life cycle.
许多寄生虫生物学中一个尚未解决的问题是，环境（或外部）信号与内在信号是如何整合，从而决定从一个发育阶段转换到下一个发育阶段的机制。这对于线虫寄生虫尤为相关，其中许多在感染哺乳动物宿主之前在环境中具有自由生活阶段，或者对于诸如丝虫线虫之类的寄生虫也是如此，它们利用昆虫媒介进行传播。寄生虫在感染哺乳动物宿主时所经历的环境变化极其复杂，人们对此了解甚少。然而，寄生虫感知其新环境的能力必然与其发育程序内在相关，因为生命周期的进展取决于感染事件。在这篇综述中，总结了丝虫线虫和自由生活物种秀丽隐杆线虫中温度与发育之间的关系，重点关注热休克因子和热休克蛋白90在线虫生命周期中的作用。
