Praticò Domenico, Rokach Joshua, Lawson John, FitzGerald Garret A
Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Chem Phys Lipids. 2004 Mar;128(1-2):165-71. doi: 10.1016/j.chemphyslip.2003.09.012.
Isoprostanes are a new class of lipids, isomers of conventional enzymatically derived prostaglandins, which are produced in vivo primarily by a free radical-catalyzed peroxidation of polyunsaturated fatty acids. F2-isoprostanes, isomers of the enzyme-derived prostaglandin F2alpha, are the most studied species. Because of their mechanisms of formation, specific structural features that distinguish them from other free radical-generated products and chemical stability, they provide a reliable index of the oxidative component of several diseases in vivo. Consistent data suggest that formation of F2-isoprostanes is indeed altered in a variety of clinical settings associated with inflammation and oxidant stress. Moreover, measurement of F2-isoprostanes might provide a sensitive biochemical basis of dose-selection in studies of natural and synthetic antioxidants.
异前列腺素是一类新的脂质，是传统酶促产生的前列腺素的异构体，主要在体内由多不饱和脂肪酸的自由基催化过氧化反应产生。F2-异前列腺素是酶促产生的前列腺素F2α的异构体，是研究最多的种类。由于其形成机制、使其有别于其他自由基生成产物的特定结构特征以及化学稳定性，它们为体内多种疾病的氧化成分提供了可靠指标。一致的数据表明，在与炎症和氧化应激相关的各种临床情况下，F2-异前列腺素的形成确实发生了改变。此外，F2-异前列腺素的测量可能为天然和合成抗氧化剂研究中的剂量选择提供一个敏感的生化基础。
