Milne Ginger L, Musiek Erik S, Morrow Jason D
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-6602, USA.
Biomarkers. 2005 Nov;10 Suppl 1:S10-23. doi: 10.1080/13547500500216546.
The isoprostanes are a unique series of prostaglandin-like compounds formed in vivo via a non-enzymatic mechanism involving the free radical-initiated peroxidation of arachidonic acid. This article summarizes selected aspects regarding current knowledge of these compounds and their value as markers of oxidative injury. Novel aspects related to the biochemistry of isoprostane formation are discussed and methods by which these compounds can be analysed and quantified are summarized. A considerable portion of this article examines the utility of F(2)-isoprostanes as markers of oxidant injury in vivo. Numerous studies carried out over the past decade have shown that these compounds are extremely accurate measures of lipid peroxidation and have illuminated the role of oxidant injury in a number of human diseases including atherosclerosis, Alzheimer's disease and pulmonary disorders.
异前列腺素是一类独特的类前列腺素化合物，通过非酶机制在体内形成，该机制涉及自由基引发的花生四烯酸过氧化反应。本文总结了关于这些化合物的现有知识及其作为氧化损伤标志物的价值的某些方面。讨论了与异前列腺素形成生物化学相关的新方面，并总结了分析和定量这些化合物的方法。本文相当一部分内容探讨了F(2)-异前列腺素作为体内氧化损伤标志物的效用。过去十年进行的大量研究表明，这些化合物是脂质过氧化的极其准确的指标，并阐明了氧化损伤在包括动脉粥样硬化、阿尔茨海默病和肺部疾病在内的多种人类疾病中的作用。
