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Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.酵母tRNA的7-甲基鸟苷修饰需要两种形成复合物的蛋白质。
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Functional profiling of the Saccharomyces cerevisiae genome.酿酒酵母基因组的功能分析。
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Identification of the TRM2 gene encoding the tRNA(m5U54)methyltransferase of Saccharomyces cerevisiae.酿酒酵母中编码tRNA（m5U54）甲基转移酶的TRM2基因的鉴定。
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The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae.Gcd10p/Gcd14p复合物是酿酒酵母中必不可少的双亚基tRNA（1-甲基腺苷）甲基转移酶。
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Evidence for the transfer of sulfane sulfur from IscS to ThiI during the in vitro biosynthesis of 4-thiouridine in Escherichia coli tRNA.在大肠杆菌tRNA中4-硫尿苷的体外生物合成过程中，硫烷硫从IscS转移至ThiI的证据。
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Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast.内含子预测测试揭示了酵母减数分裂调控基因中的新剪接位点、可变剪接的mRNA和新内含子。
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酿酒酵母TAN1基因是tRNA中N4-乙酰胞苷形成所必需的。

The Saccharomyces cerevisiae TAN1 gene is required for N4-acetylcytidine formation in tRNA.

作者信息

Johansson Marcus J O, Byström Anders S

机构信息

Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.

出版信息

RNA. 2004 Apr;10(4):712-9. doi: 10.1261/rna.5198204.

DOI:10.1261/rna.5198204
PMID:15037780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1370561/
Abstract

The biogenesis of transfer RNA is a process that requires many different factors. In this study, we describe a genetic screen aimed to identify gene products participating in this process. By screening for mutations lethal in combination with a sup61-T47:2C allele, coding for a mutant form of, the nonessential TAN1 gene was identified. We show that the TAN1 gene product is required for formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. In Saccharomyces cerevisiae, ac(4)C is present at position 12 in tRNAs specific for leucine and serine as well as in 18S ribosomal RNA. Analysis of RNA isolated from a tan1-null mutant revealed that ac(4)C was absent in tRNA, but not rRNA. Although no tRNA acetyltransferase activity by a GST-Tan1 fusion protein was detected, a gel-shift assay revealed that Tan1p binds tRNA, suggesting a direct role in synthesis of ac(4)C(12). The absence of the TAN1 gene in the sup61-T47:2C mutant caused a decreased level of mature, indicating that ac(4)C(12) and/or Tan1p is important for tRNA stability.

摘要

转运RNA的生物合成是一个需要多种不同因子的过程。在本研究中，我们描述了一项旨在鉴定参与该过程的基因产物的遗传筛选。通过筛选与编码非必需TAN1基因的突变形式的sup61-T47:2C等位基因组合时致死的突变，鉴定出了TAN1基因。我们表明，TAN1基因产物是tRNA中修饰核苷N(4)-乙酰胞苷（ac(4)C）形成所必需的。在酿酒酵母中，ac(4)C存在于亮氨酸和丝氨酸特异性tRNA的第12位以及18S核糖体RNA中。对从tan1缺失突变体中分离的RNA的分析表明，tRNA中不存在ac(4)C，但rRNA中存在。尽管未检测到GST-Tan1融合蛋白的tRNA乙酰转移酶活性，但凝胶迁移试验表明Tan1p结合tRNA，提示其在ac(4)C(12)合成中起直接作用。sup61-T47:2C突变体中TAN1基因的缺失导致成熟水平降低，表明ac(�C(12)和/或Tan1p对tRNA稳定性很重要。