Svobodová Alena, Psotová Jitka, Walterová Daniela
Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, nevotínská 3, 775 15 Olomouc, Czech Republic.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 Dec;147(2):137-45.
UV skin exposure induces extensive generation of reactive oxygen species (ROS). These can react with DNA, proteins, fatty acids and saccharides causing oxidative damage. Such injuries result in a number of harmful effects: disturbed cell metabolism, morphological and ultrastructural changes, attack on the regulation pathways and, alterations in the differentiation, proliferation and apoptosis of skin cells. These processes can lead to photoaging and skin cancer development. One approach to protecting human skin against the harmful effects of UV irradiation is to use antioxidants as photoprotectives. In recent years naturally occurring herbal compounds such as phenolic acids, flavonoids, and high molecular weight polyphenols have gained considerable attention as beneficial protective agents. In this review, we strive to summarize the findings of studies performed to date, regarding the photoprotective effects of plant phenolics on the skin damage induced by UV radiation.
紫外线照射皮肤会诱导大量活性氧（ROS）的产生。这些活性氧可与DNA、蛋白质、脂肪酸和糖类发生反应，造成氧化损伤。此类损伤会导致多种有害影响：细胞代谢紊乱、形态和超微结构变化、对调节途径的攻击以及皮肤细胞分化、增殖和凋亡的改变。这些过程可导致皮肤光老化和皮肤癌的发生。保护人类皮肤免受紫外线辐射有害影响的一种方法是使用抗氧化剂作为光保护剂。近年来，天然存在的草药化合物，如酚酸、黄酮类化合物和高分子量多酚，作为有益的保护剂受到了广泛关注。在本综述中，我们力求总结迄今为止关于植物酚类对紫外线辐射引起的皮肤损伤的光保护作用的研究结果。
