Xu Jianwen, Li Ting, Li Fei, Qiang Hong, Wei Xiaoxiao, Zhan Ruiwen, Chen Yun
Department of Nursing, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.
Department of Neurology, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.
Front Pharmacol. 2025 Jan 7;15:1461790. doi: 10.3389/fphar.2024.1461790. eCollection 2024.
Chronic wounds, especially non-healing wounds, significantly affect patients' quality of life and raise the costs of therapy. Wound healing is a complicated process involving interdependent stages, which may be impaired and delayed by infections with multi-drug resistant pathogens. Current medical strategies for wound healing, especially the treatment of non-healing wounds, exert limited therapeutic effects, thus become a dramatic challenge for modern medicine. There has been growing interest in exploring complementary approaches to enhance the wound healing process, and complementary therapy using herbs and their related products has gained increasing attention. Apart from skin wounds, dermal pathological changes caused by UV irradiation, may also benefit from such complementary therapy. The antimicrobial, anti-inflammatory, antioxidant, analgesic and collagen-promoting properties of extract from L. (rosemary) have all been considered to contribute to the beneficial effects on different stages and multiple aspects of skin recovery after various wounds or UV irradiation. This review aims to summarize the applications and their underlying mechanisms of rosemary as part of the complementary therapy for injured and UV-irradiated skin based on the currently available evidence. The medicinal properties of rosemary and its application in wound dressing are first discussed, followed by summarization of its application in different types of wounds. A conclusion is reached and future directions are discussed. As research in this area continue to evolve, rosemary-derived products may become an integral part of holistic wound care strategies, offering a complementary approach to conventional treatments.
慢性伤口，尤其是难愈合伤口，会显著影响患者的生活质量并增加治疗成本。伤口愈合是一个复杂的过程，涉及相互依存的多个阶段，而多重耐药病原体感染可能会损害并延缓这一过程。当前用于伤口愈合的医学策略，尤其是针对难愈合伤口的治疗，其治疗效果有限，因此成为现代医学面临的一项严峻挑战。人们越来越有兴趣探索辅助方法来加速伤口愈合过程，使用草药及其相关产品的辅助疗法也越来越受到关注。除皮肤伤口外，紫外线照射引起的皮肤病理变化也可能从这种辅助疗法中受益。迷迭香叶提取物的抗菌、抗炎、抗氧化、止痛和促进胶原蛋白生成的特性，都被认为有助于对各种伤口或紫外线照射后皮肤恢复的不同阶段和多个方面产生有益影响。本综述旨在根据现有证据，总结迷迭香作为辅助疗法用于受伤和紫外线照射皮肤的应用及其潜在机制。首先讨论迷迭香的药用特性及其在伤口敷料中的应用，然后总结其在不同类型伤口中的应用。最后得出结论并讨论未来的研究方向。随着该领域研究的不断发展，迷迭香衍生产品可能会成为整体伤口护理策略的一个组成部分，为传统治疗提供一种辅助方法。
