Jeon H Y, Kim J K, Kim W G, Lee S J
Food Research Institute, Amorepacific Corporation R&D Center, Yongin, Korea.
Skin Pharmacol Physiol. 2009;22(3):137-41. doi: 10.1159/000201562. Epub 2009 Feb 12.
BACKGROUND/AIMS: Excessive exposure to UV radiation causes acute adverse effects like sunburn and photosensitivity reactions and is involved in the induction and development of skin cancer. It has been reported that antioxidants have photoprotective effects against solar UV radiation. We investigated the effect of oral epigallocatechin gallate (EGCG), a powerful antioxidant in green tea, on the minimal erythema dose (MED) and UV-induced skin damage.
Female HWY/Slc hairless rats were fed the normal diet supplemented with 1,500 ppm EGCG for 8 weeks; then, the MED was determined and visual scores and transepidermal water loss were assessed to evaluate the severity of UV-induced skin damage.
At week 8 of the study, the use of dietary EGCG significantly increased MED. UV-radiation-induced sunburn severity and alterations in epidermal barrier function were also attenuated by the supplementation of EGCG.
Regular intake of EGCG strengthens the skin's tolerance by increasing MED and thus prevents UV-induced perturbation of epidermal barrier function and skin damage. These results suggest that EGCG is a potent candidate for systemic photoprotection.
背景/目的：过度暴露于紫外线辐射会导致晒伤和光敏反应等急性不良反应，并参与皮肤癌的诱发和发展。据报道，抗氧化剂对太阳紫外线辐射具有光保护作用。我们研究了口服表没食子儿茶素没食子酸酯（EGCG）（绿茶中的一种强大抗氧化剂）对最小红斑量（MED）和紫外线诱导的皮肤损伤的影响。
将雌性HWY/Slc无毛大鼠喂食补充有1500 ppm EGCG的正常饮食8周；然后，测定MED，并评估视觉评分和经表皮水分流失，以评估紫外线诱导的皮肤损伤的严重程度。
在研究的第8周，饮食中使用EGCG显著增加了MED。补充EGCG也减轻了紫外线辐射引起的晒伤严重程度和表皮屏障功能的改变。
定期摄入EGCG可通过增加MED来增强皮肤耐受性，从而防止紫外线引起的表皮屏障功能紊乱和皮肤损伤。这些结果表明，EGCG是全身光保护的有力候选者。
