Noutsias Michel, Pauschinger Matthias, Poller Wolfgang-Christian, Schultheiss Heinz-Peter, Kühl Uwe
Department of Cardiology and Pneumonology, Charité-University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany.
Expert Rev Cardiovasc Ther. 2004 Jan;2(1):37-51. doi: 10.1586/14779072.2.1.37.
Chronic autoimmunity and viral persistence constitute prognostic factors for adverse outcome in dilated cardiomyopathy patients. Inflammatory cardiomyopathy is a specific cardiomyopathy entity diagnosed in approximately 50% of dilated cardiopmyopathy patients by immunohistological quantification of immunocompetent infiltrates and cell adhesion molecule abundance. Patients with autoimmune inflammatory cardiomyopathy benefit from immunosuppressive treatment and immunoadsorption by improvement of left ventricular ejection fraction and heart failure symptoms, paralleled by a significant suppression of intramyocardial inflammation. However, dilated cardiomyopathy patients with viral persistence do not respond favorably to immunosuppression.
慢性自身免疫和病毒持续感染是扩张型心肌病患者不良预后的预后因素。炎症性心肌病是一种特殊的心肌病实体，通过对免疫活性浸润和细胞粘附分子丰度进行免疫组织学定量分析，在约50%的扩张型心肌病患者中被诊断出来。自身免疫性炎症性心肌病患者通过改善左心室射血分数和心力衰竭症状，以及显著抑制心肌内炎症，从免疫抑制治疗和免疫吸附中获益。然而，病毒持续感染的扩张型心肌病患者对免疫抑制治疗反应不佳。
