Heard Isabelle, Palefsky Joel M, Kazatchkine Michel D
Institut National de la Santé et de la Recherche Médicale U430 and Unite d'Immunologie Clinique, Hôpital Européen G Pompidou, Paris, France.
Antivir Ther. 2004 Feb;9(1):13-22.
Human papillomavirus (HPV) infections play an important role in the pathogenesis of anogenital cancer and its precursors. HIV-infected individuals exhibit a high prevalence of HPV DNA. Several studies have further shown that HIV-infected individuals have an increased prevalence of squamous intraepithelial lesions (SIL) of the cervix, vulva and anus. The incidence of invasive cervical cancer is also elevated in HIV-positive women as well as that of anal cancer in HIV-positive women and men. Given the relationship between HIV-induced immunosuppression and HPV-associated disease, treatment with highly active antiretroviral therapy (HAART) has the potential, through immune reconstitution of the host, to alter the natural history of HPV infection and SIL. However, data on the impact of HAART on HPV disease are sparse and mixed results have been reported.
人乳头瘤病毒（HPV）感染在肛门生殖器癌及其癌前病变的发病机制中起重要作用。HIV感染者中HPV DNA的患病率很高。多项研究进一步表明，HIV感染者宫颈、外阴和肛门的鳞状上皮内病变（SIL）患病率增加。HIV阳性女性的浸润性宫颈癌发病率以及HIV阳性女性和男性的肛门癌发病率也有所升高。鉴于HIV诱导的免疫抑制与HPV相关疾病之间的关系，高效抗逆转录病毒疗法（HAART）通过宿主免疫重建，有可能改变HPV感染和SIL的自然病程。然而，关于HAART对HPV疾病影响的数据稀少，且报告的结果不一。
