Tsumura Munechika, Makihara Seiichiro, Nishikori Asami, Gion Yuka, Morito Toshiaki, Miyamoto Shotaro, Naito Tomoyuki, Uraguchi Kensuke, Oka Aiko, Tachibana Tomoyasu, Orita Yorihisa, Kariya Shin, Okano Mitsuhiro, Ando Mizuo, Sato Yasuharu
Department of Otolaryngology Head and Neck Surgery, Kagawa Rosai Hospital, Marugame 763-8502, Japan.
Department of Otolaryngology Head and Neck Surgery, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Okayama 700-8558, Japan.
Diagnostics (Basel). 2022 Feb 10;12(2):454. doi: 10.3390/diagnostics12020454.
Sinonasal inverted papilloma (SNIP) can recur; however, the factors related to tumor recurrence remain unclear. This study aimed to analyze risk factors, including human papillomavirus (HPV) infection, as well as other factors associated with SNIP recurrence. Thirty-two patients who were diagnosed with SNIP and underwent surgery between 2010 and 2019 were enrolled: 24 men and 8 women, with a mean age of 59.2 years. The mean follow-up was 57.3 months. Demographics and information about history of smoking, diabetes mellitus (DM), hypertension, allergic rhinitis, alcohol consumption, tumor stage, surgical approach, and recurrence were reviewed retrospectively. Specimens were investigated using polymerase chain reaction to detect HPV DNA (high-risk subtypes: 16, 18, 31, 33, 35, 52b, and 58; low-risk subtypes: 6 and 11). Seven patients (21.9%) experienced recurrence. HPV DNA was detected in five (15.6%) patients (high-risk subtypes, = 2; low-risk subtypes, = 3). Patients with recurrence of SNIP had a higher proportion of young adults and displayed higher rates of HPV infection, DM, and advanced tumor stage than those without recurrence. HPV infection, young adulthood, DM, and advanced tumor stage could be associated with a high recurrence rate, which suggests that patients with these risk factors could require close follow-up after surgery.
鼻窦内翻性乳头状瘤（SNIP）可复发；然而，与肿瘤复发相关的因素仍不清楚。本研究旨在分析包括人乳头瘤病毒（HPV）感染在内的危险因素以及与SNIP复发相关的其他因素。纳入了32例在2010年至2019年间被诊断为SNIP并接受手术的患者：24例男性和8例女性，平均年龄59.2岁。平均随访时间为57.3个月。回顾性分析了人口统计学资料以及吸烟史、糖尿病（DM）、高血压、过敏性鼻炎、饮酒情况、肿瘤分期手术方式和复发情况等信息。使用聚合酶链反应对标本进行检测以检测HPV DNA（高危亚型：16、18、31、33、35、52b和58；低危亚型：6和11）。7例患者（21.9%）复发。5例（15.6%）患者检测到HPV DNA（高危亚型，2例；低危亚型，3例）。与未复发患者相比，SNIP复发患者中年轻人的比例更高，HPV感染、DM和肿瘤晚期的发生率也更高。HPV感染、年轻成年、DM和肿瘤晚期可能与高复发率相关，这表明具有这些危险因素的患者术后可能需要密切随访。
