Remme Jan H F
Intervention Development and Implementation Research, UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, WHO, Geneva, Switzerland.
Trop Med Int Health. 2004 Feb;9(2):243-54. doi: 10.1046/j.1365-3156.2003.01192.x.
Onchocerciasis control has been very successful in Africa and research has played a critical role. An overview of the main epidemiological and implementation research activities undertaken over the last 20 years in collaboration with the African onchocerciasis control programmes and of the impact this research had on control is given. The research included the development of epidemiological modelling and its application in programme evaluation and operational planning, research on disease patterns and disease burden in different bioclimatic zones to justify and guide control operations, community trials of ivermectin to determine its safety for large-scale use and its impact on transmission, rapid assessment methods to identify target communities for treatment and community-directed treatment for sustained drug delivery. Lessons learned during this unique collaboration between research and control are discussed.
盘尾丝虫病防治工作在非洲取得了巨大成功，研究发挥了关键作用。本文概述了过去20年与非洲盘尾丝虫病防治计划合作开展的主要流行病学和实施研究活动，以及该研究对防治工作的影响。这些研究包括流行病学模型的开发及其在项目评估和运营规划中的应用，不同生物气候区疾病模式和疾病负担的研究，以证明和指导防治行动，伊维菌素的社区试验，以确定其大规模使用的安全性及其对传播的影响，快速评估方法以确定治疗目标社区以及社区导向治疗以实现持续药物输送。文中还讨论了在研究与防治这一独特合作过程中吸取的经验教训。
