Summerbell C D, Youle M, McDonald V, Catalan J, Gazzard B G
HIV/GUM Unit, Kobler Centre (St Stephen's Clinic), London, UK.
Int J STD AIDS. 1992 Jul-Aug;3(4):278-80. doi: 10.1177/095646249200300409.
Two appetite stimulants, megestrol acetate and cyproheptadine were administered in a randomized trial to 14 patients who had no evidence of opportunistic infection or malabsorption but were wasted (had lost more than 5 kg body weight) as a result of human immunodeficiency virus (HIV) infection. Energy intakes were calculated from a 7 day weighed dietary record. Mean energy intakes per kilogramme body weight were similar in both treatment groups (greater than 34 kcal/kg) and were higher than that in well British males. Energy intakes increased by just over 500 kcal during both treatments, but fell to pretreatment levels after therapy. Patients in both treatment groups gained a moderate amount of weight. Megestrol acetate was associated with impotence in 4 patients. Insufficient calorie intake alone is not a common cause of wasting associated with HIV and the role of appetite stimulants is likely to be limited.
在一项随机试验中，对14名没有机会性感染或吸收不良证据，但因人类免疫缺陷病毒（HIV）感染而消瘦（体重减轻超过5公斤）的患者使用了两种食欲刺激剂，醋酸甲地孕酮和赛庚啶。能量摄入量根据7天的称重饮食记录计算得出。两个治疗组每公斤体重的平均能量摄入量相似（大于34千卡/公斤），且高于健康英国男性的摄入量。在两种治疗期间，能量摄入量均增加了略超过500千卡，但治疗后降至治疗前水平。两个治疗组的患者体重都有适度增加。醋酸甲地孕酮使4名患者出现阳痿。单纯热量摄入不足并非与HIV相关消瘦的常见原因，食欲刺激剂的作用可能有限。
