人类中性粒细胞抗原-2a（NB1）表达及中性粒细胞数量在妊娠中的意义。
Significance of human neutrophil antigen-2a (NB1) expression and neutrophil number in pregnancy.
作者信息
Taniguchi Kikuyo, Nagata Hideaki, Katsuki Takafumi, Nakashima Chiyoko, Onodera Rie, Hiraoka Asako, Takata Noboru, Kobayashi Masao, Kambe Masayuki
机构信息
Hiroshima College of Medical Technology, Hatsukaichi, Japan.
出版信息
Transfusion. 2004 Apr;44(4):581-5. doi: 10.1111/j.1537-2995.2004.03298.x.
BACKGROUND
Expression of human neutrophil antigen-2a (HNA-2a) is greater in women than in men. The size of the HNA-2a-positive neutrophil population increases with pregnancy.
STUDY DESIGN AND METHODS
T he relationship between HNA-2a expression on neutrophils and monocytes, and their relative numbers, was investigated. HNA-2a expression shown as the size of the HNA-2a-positive cell population and the fluorescence intensity on the cells was analyzed using flow cytometry. This investigation was done among 165 pregnant women during pregnancy and postpartum.
RESULTS
In normal pregnancy, numbers of neutrophils and monocytes changed in relation to HNA-2a expression. HNA-2a was also expressed intensively on monocytes from some pregnant women in the first and second trimesters. HNA-2a expression and the number of cells markedly decreased postpartum. In threatened premature labor, the number of neutrophils decreased earlier than in normal pregnancy.
CONCLUSION
HNA-2a expression may increase soon after fertilization. In this study, the results indicate that the change in the number of neutrophils and monocytes is related to HNA-2a expression.
背景
人类中性粒细胞抗原-2a（HNA-2a）在女性中的表达高于男性。HNA-2a阳性中性粒细胞群体的大小随妊娠而增加。
研究设计与方法
研究了中性粒细胞和单核细胞上HNA-2a的表达及其相对数量之间的关系。使用流式细胞术分析以HNA-2a阳性细胞群体大小和细胞上荧光强度表示的HNA-2a表达。本研究在165名孕妇孕期及产后进行。
结果
在正常妊娠中，中性粒细胞和单核细胞的数量与HNA-2a表达相关。在妊娠早期和中期，部分孕妇的单核细胞上也强烈表达HNA-2a。产后HNA-2a表达及细胞数量明显减少。在先兆早产中，中性粒细胞数量比正常妊娠更早减少。
结论
受精后不久HNA-2a表达可能增加。在本研究中，结果表明中性粒细胞和单核细胞数量的变化与HNA-2a表达有关。
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