Vial T, Pont J, Pham E, Rabilloud M, Descotes J
Service de Pharmaco-Toxicovigilance, Hôpital Edouard Herriot, Lyon, France.
Ann Pharmacother. 1992 Jul-Aug;26(7-8):910-4. doi: 10.1177/106002809202600708.
To describe the clinical features of serum sickness-like diseases (SSLD) in cefaclor-treated patients.
Analysis of a case series spontaneously reported to Lyons Pharmacovigilance Center.
General and hospital practitioners and the French Network of Regional Pharmacovigilance Centers (FNRPC).
All reported cases with a possible causative relationship between cefaclor treatment and SSLD.
Eight cases of SSLD following cefaclor treatment are described. The clinical features included cutaneous reactions, arthralgias, and moderate hyperthermia. In 50 percent of the patients, hospitalization was required because of incapacitating symptoms. The outcome was benign in all cases following discontinuation of the offending drug. All eight cases were reported in children under five years of age. Among 137 cefaclor-associated drug reactions collected by FNRPC, 27 cases of SSLD have been reported; 23 of these patients were younger than five years of age. A literature survey confirmed the higher reporting of SSLD in children with cefaclor compared with other antibiotics and suggested an incidence of 0.024-0.2 percent of SSLD per drug course of cefaclor.
The case reports and epidemiologic studies confirmed the presumed role of age (patients under five years of age) in cefaclor-induced SSLD and the benign outcome despite severe clinical presentations in some reports.
描述接受头孢克洛治疗的患者血清病样疾病（SSLD）的临床特征。
对自发上报至里昂药物警戒中心的一系列病例进行分析。
普通科及医院医生以及法国地区药物警戒中心网络（FNRPC）。
所有报告的病例均为头孢克洛治疗与SSLD之间可能存在因果关系的病例。
描述了8例头孢克洛治疗后发生SSLD的病例。临床特征包括皮肤反应、关节痛和中度发热。50%的患者因症状严重而需要住院治疗。停用致病药物后，所有病例的预后均良好。所有8例病例均为5岁以下儿童。在FNRPC收集的137例与头孢克洛相关的药物不良反应中，已报告27例SSLD；其中23例患者年龄小于5岁。一项文献调查证实，与其他抗生素相比，头孢克洛治疗的儿童中SSLD的报告率更高，提示头孢克洛每个疗程发生SSLD的发生率为0.024%至0.2%。
病例报告和流行病学研究证实了年龄（5岁以下患者）在头孢克洛诱发的SSLD中的假定作用，以及尽管在一些报告中有严重的临床表现，但预后良好。
