Department of Genetics, Dr,ALMPGIBMS, University of Madras, Chennai, -600113, India.
Thromb J. 2012 Aug 14;10(1):13. doi: 10.1186/1477-9560-10-13.
Obesity, characterised by increased fat mass and is currently regarded as a pro-inflammatory state and often associated with increased risk of cardiovascular diseases (CVD) including Myocardial infarction. There is an upregulation of inflammatory markers such as interleukin-6, interleukin-6 receptor and acute phase protein CRP in Acute Myocardial Infarction (AMI) patients but the exact mechanism linking obesity and inflammation is not known. It is of our interest to investigate if serum leptin (ob gene product) is associated with AMI and correlated with inflammatory proteins namely Interleukin-6 (IL-6) and high sensitivity - C reactive protein (hs-CRP).
Serum leptin levels were significantly higher in AMI patients when compared to Non-CVD controls. IL-6 and hs-CRP were also elevated in the AMI group and leptin correlated positively with IL-6 and hs-CRP. Incidentally this is the first report from Chennai based population, India.
The strong correlation between serum levels of leptin and IL-6 implicates an involvement of leptin in the upregulation of inflammatory cytokines during AMI. We hypothesise that the increase in values of IL-6, hs-CRP and their correlation to leptin in AMI patients could be due to participation of leptin in the signaling cascade after myocardial ischemia.
肥胖的特点是脂肪量增加，目前被认为是一种炎症状态，常与心血管疾病（CVD）风险增加相关，包括心肌梗死。在急性心肌梗死（AMI）患者中，炎症标志物如白细胞介素-6（IL-6）、白细胞介素-6 受体和急性相蛋白 CRP 等会出现上调，但肥胖与炎症之间的确切联系机制尚不清楚。我们有兴趣研究血清瘦素（ob 基因产物）是否与 AMI 相关，并与炎症蛋白如白细胞介素-6（IL-6）和高敏 C 反应蛋白（hs-CRP）相关。
与非 CVD 对照组相比，AMI 患者的血清瘦素水平显著升高。AMI 组的 IL-6 和 hs-CRP 也升高，瘦素与 IL-6 和 hs-CRP 呈正相关。顺便说一句，这是来自印度钦奈的人群的首次报告。
血清瘦素水平与 IL-6 之间的强烈相关性表明，瘦素参与了 AMI 期间炎症细胞因子的上调。我们假设 AMI 患者中 IL-6、hs-CRP 值的增加及其与瘦素的相关性可能是由于瘦素在心肌缺血后的信号级联反应中参与。
