Militzer K, Büttner D, Moog E
Central Animal Laboratory, University of Essen, Germany.
Exp Toxicol Pathol. 1992 Jun;44(3):113-24. doi: 10.1016/S0940-2993(11)80141-7.
The allometric relations, i.e. bodily characteristics, body weight-relationships as well as age-dependent organ and biochemical data were studied in a total of 464 golden hamsters of both sexes of an acromelanic white inbred and agouti coloured outbred strain. In the 3 age sections studied (I = day 1-20, II = day 25-100, III = day 110-365) the body weight- and age-dependent relations were found to be altered between and within the various characteristics. The body weight correlations predominated in the case of organ weights and skin muscle thickness. By contrast, age correlations were seen above all in the skin compartments with cyclic growth, hair follicle density and reticular thickness in the age sections I and II. Papillary thickness showed a positive relation to body weight and age after weaning, but no long-term relations were observed with both plasma insulin and blood glucose levels. The allometric behaviour of skin compartments could be explained particularly by thermoregulatory and "geometric" similarities and that of the organs by metabolic and other similarities. Most sex and strain differences in the absolute data, except for the kidney and adrenal weights, disappeared on allometric analysis and were thus mainly due to differences in body weight. For long-term toxicological investigations, the documentation of age and body weight as well as the determination of ontogenetic allometry is a "must".
对464只金仓鼠进行了研究，这些金仓鼠来自一个肢端黑色素沉着白色近交品系和一个刺豚鼠色远交品系，涵盖了两性。研究了3个年龄段（I = 第1 - 20天，II = 第25 - 100天，III = 第110 - 365天），发现不同特征之间以及同一特征内部，体重与年龄的关系均有所改变。在器官重量和皮肤肌肉厚度方面，体重相关性占主导。相比之下，年龄相关性主要出现在I和II年龄段具有周期性生长的皮肤区域、毛囊密度和网状厚度上。断奶后乳头厚度与体重和年龄呈正相关，但与血浆胰岛素和血糖水平均未观察到长期关系。皮肤区域的异速生长行为尤其可以通过体温调节和“几何”相似性来解释，而器官的异速生长行为则可以通过代谢和其他相似性来解释。除肾脏和肾上腺重量外，绝对数据中的大多数性别和品系差异在异速分析后消失，因此主要是由于体重差异所致。对于长期毒理学研究，记录年龄和体重以及确定个体发育异速生长是“必须的”。
