Huddleston Hailey P, Cohn Matthew R, Haunschild Eric D, Wong Stephanie E, Farr Jack, Yanke Adam B
Department of Orthopaedic Surgery, Division of Sports Medicine, Rush University Medical Center, 1611 W. Harrison St, Suite 300, Chicago, IL, 60612, USA.
Knee Preservation and Cartilage Restoration Center, OrthoIndy, Indianapolis, IN, USA.
Curr Rev Musculoskelet Med. 2020 Apr;13(2):148-154. doi: 10.1007/s12178-020-09614-2.
Orthobiologics, including amniotic products, have been gaining interest in the past decade for the treatment of various orthopedic conditions including osteoarthritis. However, the use of biologics is varied and is currently available with minimal oversight or regulation. This review will assess the current state of research that utilizes amniotic products both in vitro and in vivo.
Amniotic tissue derivatives have been shown to have positive effects in animal models for a variety of conditions. Clinical trials are limited with mixed outcomes, yet some recent studies suggest the rationale for continued investigation. While amniotic products appear promising in numerous animal studies, human clinical trials are still lacking. Future studies are needed to assess whether amniotic products have a role in the treatment of osteoarthritis and other orthopedic pathologies.
包括羊膜产品在内的骨科生物制剂在过去十年中越来越受到关注，用于治疗包括骨关节炎在内的各种骨科疾病。然而，生物制剂的使用方式各不相同，目前在监管最少的情况下即可获得。本综述将评估利用羊膜产品进行体外和体内研究的现状。
羊膜组织衍生物已在多种疾病的动物模型中显示出积极作用。临床试验有限且结果不一，但最近的一些研究表明有继续研究的理由。虽然羊膜产品在众多动物研究中看起来很有前景，但人类临床试验仍然缺乏。未来需要进行研究，以评估羊膜产品在骨关节炎和其他骨科疾病治疗中是否发挥作用。
