脐血中淋巴细胞亚群的特征分析。
Characterization of lymphocyte subpopulations in cord blood.
作者信息
Rabian-Herzog C, Lesage S, Gluckman E
机构信息
Laboratory of Immunology and Histocompatibility, Hôpital Saint-Louis, Paris, France.
出版信息
Bone Marrow Transplant. 1992;9 Suppl 1:64-7.
27 cord blood samples from healthy newborns were processed according to a "whole blood" flow cytometric analysis. The CD3-positive T cells are characterized by their variability: 44.8 +/- 13.3% of lymphocytes with a lower expression of the gamma delta T cell receptor. The majority of the CD3+ cells are CD38+. Newborn T cells have less ability than adult T cells to express IL-2 receptors as well as HLA-DR. The CD4-positive T cells are equal to 31.0 +/- 10.8% of lymphocytes with a great prevalence of the CD4+/CD45RA+ population. The CD3+/CD8+/CD11b+ cells are increased to 23.4 +/- 7.1% of lymphocytes. The CD57 antigen is not expressed. The NK population, CD16+/CD56+ is increased to 25 +/- 11% of lymphocytes. 68% of CD19+ cord blood B lymphocytes coexpressed CD5. Thus the "suppressive" and "naïve" cells are prominently represented in cord blood.
对27份健康新生儿的脐带血样本按照“全血”流式细胞术分析方法进行处理。CD3阳性T细胞具有变异性：44.8±13.3%的淋巴细胞表达较低水平的γδT细胞受体。大多数CD3+细胞为CD38+。新生儿T细胞表达IL-2受体以及HLA-DR的能力低于成人T细胞。CD4阳性T细胞占淋巴细胞的31.0±10.8%，其中CD4+/CD45RA+群体占比很高。CD3+/CD8+/CD11b+细胞增加至淋巴细胞的23.4±7.1%。未表达CD57抗原。NK群体，即CD16+/CD56+增加至淋巴细胞的25±11%。68%的CD19+脐带血B淋巴细胞共表达CD5。因此，“抑制性”和“幼稚”细胞在脐带血中占显著比例。
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