Gimbel Jonathan A, Van Kleunen Jonathan P, Mehta Samir, Perry Stephanie M, Williams Gerald R, Soslowsky Louis J
McKay Orthopaedic Research Laboratory, University of Pennsylvania, 424 Stemmler Hall, 36th and Hamilton Walk, Philadelphia, PA 19104-6081, USA.
J Biomech. 2004 May;37(5):739-49. doi: 10.1016/j.jbiomech.2003.09.019.
Rotator cuff tears of the shoulder are a common cause of pain and disability. The successful repair of rotator cuff tendon tears depends on the time from onset of injury to the time of surgical repair. However, the effect of time from injury to repair remains poorly understood. A rat model was used to investigate the supraspinatus tendon organizational and mechanical property changes that occur with time post-injury to understand the natural injury response in the absence of repair. It was hypothesized that increased time post-injury would result in increased detrimental changes to tendon organizational and mechanical properties. Tendons were detached at the insertion on the humerus without repair and the quantitative organizational and mechanical properties were analyzed at 1, 2, 4, 8, and 16 weeks post-detachment. Tendon detachment resulted in a dramatic decrease in mechanical properties initially followed by a progressive increase with time. The quantitative collagen fiber orientation results provided corroborating support to the mechanical property data. Based on similarities in histology and mechanical properties to rotator cuff tears in humans, the animal model presented here is promising for future investigations of the tendon's natural injury response in the absence of repair.
肩部的肩袖撕裂是疼痛和功能障碍的常见原因。肩袖肌腱撕裂的成功修复取决于从受伤开始到手术修复的时间。然而，从受伤到修复的时间所产生的影响仍知之甚少。使用大鼠模型来研究冈上肌腱在损伤后随时间发生的组织学和力学性能变化，以了解在未进行修复的情况下的自然损伤反应。研究假设是，受伤后时间延长会导致肌腱组织学和力学性能的有害变化增加。在肱骨附着点处切断肌腱而不进行修复，并在切断后1、2、4、8和16周分析其定量组织学和力学性能。肌腱切断最初导致力学性能急剧下降，随后随时间逐渐增加。定量胶原纤维取向结果为力学性能数据提供了佐证。基于与人类肩袖撕裂在组织学和力学性能上的相似性，本文提出的动物模型对于未来研究肌腱在未修复情况下的自然损伤反应具有前景。
