导电性，一种逆转肩袖肌肉退变的再生工程方法。

Saveh-Shemshaki Nikoo, Barajaa Mohammed A, Otsuka Takayoshi, Mirdamadi Elnaz S, Nair Lakshmi S, Laurencin Cato T

The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, Farmington, CT 06030, USA.

Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.

Regen Biomater. 2023 Nov 11;10:rbad099. doi: 10.1093/rb/rbad099. eCollection 2023.

Muscle degeneration is one the main factors that lead to the high rate of retear after a successful repair of rotator cuff (RC) tears. The current surgical practices have failed to treat patients with chronic massive rotator cuff tears (RCTs). Therefore, regenerative engineering approaches are being studied to address the challenges. Recent studies showed the promising outcomes of electroactive materials (EAMs) on the regeneration of electrically excitable tissues such as skeletal muscle. Here, we review the most important biological mechanism of RC muscle degeneration. Further, the review covers the recent studies on EAMs for muscle regeneration including RC muscle. Finally, we will discuss the future direction toward the application of EAMs for the augmentation of RCTs.

肌肉退变是导致肩袖（RC）撕裂成功修复后再撕裂率较高的主要因素之一。目前的外科手术方法未能有效治疗慢性巨大肩袖撕裂（RCT）患者。因此，人们正在研究再生工程方法以应对这些挑战。最近的研究表明，电活性材料（EAM）在骨骼肌等电可兴奋组织的再生方面具有良好前景。在此，我们综述了RC肌肉退变最重要的生物学机制。此外，本综述涵盖了近年来关于EAM用于肌肉再生（包括RC肌肉）的研究。最后，我们将讨论EAM应用于增强RCT修复的未来方向。