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万古霉素耐药肠球菌中vanA基因簇重排导致糖肽类耐药性降低。

Reduction in glycopeptide resistance in vancomycin-resistant enterococci as a result of vanA cluster rearrangements.

作者信息

Lee Wee Gyo, Huh Ji Young, Cho Sung Ran, Lim Young Ae

机构信息

Department of Laboratory Medicine, Ajou University School of Medicine, Suwon, South Korea.

出版信息

Antimicrob Agents Chemother. 2004 Apr;48(4):1379-81. doi: 10.1128/AAC.48.4.1379-1381.2004.

DOI:10.1128/AAC.48.4.1379-1381.2004
PMID:15047548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC375328/
Abstract

The molecular characterization of five clinical isolates of vanA-containing vancomycin-resistant enterococci with altered resistance to glycopeptides was examined. One strain represented an IS1216V insertion accompanied by partial deletion of the reading frame of vanX following a transposition event. The other four strains represented IS1216V within the vanX-vanY intergenic region associated with deletion of vanY or vanZ.

摘要

对五株含vanA的耐万古霉素肠球菌临床分离株进行了分子特征分析，这些菌株对糖肽类抗生素的耐药性发生了改变。一株菌株表现为IS1216V插入，伴随转座事件后vanX阅读框的部分缺失。另外四株菌株表现为vanX-vanY基因间区域内的IS1216V，与vanY或vanZ的缺失相关。

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