新型喹诺酮类药物对携带质粒介导喹诺酮耐药决定子qnr的大肠埃希菌和肺炎克雷伯菌的活性。
Activities of newer quinolones against Escherichia coli and Klebsiella pneumoniae containing the plasmid-mediated quinolone resistance determinant qnr.
作者信息
Wang Minggui, Sahm Daniel F, Jacoby George A, Zhang Yingyuan, Hooper David C
机构信息
Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
出版信息
Antimicrob Agents Chemother. 2004 Apr;48(4):1400-1. doi: 10.1128/AAC.48.4.1400-1401.2004.
Abstract
Seventeen qnr-containing transconjugants were constructed with azide-resistant Escherichia coli J53 as the recipient, and the MICs of 12 quinolones were tested by agar dilution methods. Sitafloxacin, BAYy3118, and premafloxacin had higher activity in vitro than ciprofloxacin against transconjugants and donors containing qnr. The donors had higher quinolone MICs than the transconjugants.
摘要
以叠氮化物抗性大肠杆菌J53作为受体构建了17个含qnr的接合子，并通过琼脂稀释法检测了12种喹诺酮类药物的最低抑菌浓度（MIC）。司帕沙星、BAYy3118和普马沙星在体外对含qnr的接合子和供体的活性高于环丙沙星。供体的喹诺酮类MIC高于接合子。
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