泰勒氏病毒的前导蛋白会干扰细胞蛋白的核质运输。
The leader protein of Theiler's virus interferes with nucleocytoplasmic trafficking of cellular proteins.
作者信息
Delhaye Sophie, van Pesch Vincent, Michiels Thomas
机构信息
Christian de Duve Institute of Cellular Pathology, University of Louvain, MIPA-VIRO 74-49, B-1200 Brussels, Belgium.
出版信息
J Virol. 2004 Apr;78(8):4357-62. doi: 10.1128/jvi.78.8.4357-4362.2004.
Abstract
The leader protein of Theiler's virus was previously shown to block the production of alpha/beta interferon by infected cells. Here, we observed that expression of the leader protein in infected cells triggered subcellular redistribution of a nucleus-target green fluorescent protein. It enhanced redistribution of the nuclear polypyrimidine tract-binding protein but had no influence on the localization of the nuclear splicing factor SC-35. The leader protein also interfered with trafficking of the cytoplasmic interferon regulatory factor 3, a factor critical for transcriptional activation of alpha/beta interferon genes.
摘要
此前研究表明，泰勒氏病毒的前导蛋白可阻断受感染细胞中α/β干扰素的产生。在此，我们观察到受感染细胞中前导蛋白的表达引发了一种靶向细胞核的绿色荧光蛋白的亚细胞重新分布。它增强了核多嘧啶序列结合蛋白的重新分布，但对核剪接因子SC-35的定位没有影响。前导蛋白还干扰了细胞质中干扰素调节因子3的运输，该因子对α/β干扰素基因的转录激活至关重要。
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