通过体内微透析测量，快速眼动睡眠期间延髓尾内侧乙酰胆碱释放增强。
Enhancement of acetylcholine release during REM sleep in the caudomedial medulla as measured by in vivo microdialysis.
作者信息
Kodama T, Lai Y Y, Siegel J M
机构信息
VAMC, Sepulveda, CA 91343.
出版信息
Brain Res. 1992 May 15;580(1-2):348-50. doi: 10.1016/0006-8993(92)90967-e.
Abstract
Previous studies in our laboratory have found that muscle atonia could be triggered by two distinct areas of the medial medulla, a caudal region, corresponding to the nucleus paramedianus (NPM) and a rostral region, corresponding to the nucleus magnocellularis (NMC). The former region is responsive to acetylcholine (ACh) and the latter region is responsive to glutamate. In this study we have measured the endogenous ACh release across the sleep-wake cycle in these two areas with the microdialysis technique in unanesthetized, freely moving cats. We found that ACh release in NPM was state-dependent and was about 30% higher (P less than 0.001) during rapid eye movement (REM) sleep than during slow-wave sleep and wakefulness. However, ACh release in NMC was not selectively elevated in REM sleep. The enhancement of ACh release in NPM during REM sleep supports our hypothesis that ACh release onto cholinoceptive neurons in this area mediates the muscle atonia of REM sleep.
摘要
我们实验室之前的研究发现，延髓内侧的两个不同区域可引发肌肉张力缺失，一个是尾侧区域，对应旁正中核（NPM），另一个是头侧区域，对应巨细胞网状核（NMC）。前一个区域对乙酰胆碱（ACh）有反应，后一个区域对谷氨酸有反应。在本研究中，我们用微透析技术在未麻醉、自由活动的猫身上测量了这两个区域在睡眠-觉醒周期中的内源性ACh释放。我们发现，NPM中的ACh释放与睡眠状态有关，在快速眼动（REM）睡眠期间比在慢波睡眠和清醒时高约30%（P<0.001）。然而，NMC中的ACh释放在REM睡眠中并没有选择性升高。REM睡眠期间NPM中ACh释放的增强支持了我们的假设，即该区域向胆碱能感受神经元释放的ACh介导了REM睡眠中的肌肉张力缺失。
相似文献
1
Enhancement of acetylcholine release during REM sleep in the caudomedial medulla as measured by in vivo microdialysis.通过体内微透析测量，快速眼动睡眠期间延髓尾内侧乙酰胆碱释放增强。
Brain Res. 1992 May 15;580(1-2):348-50. doi: 10.1016/0006-8993(92)90967-e.
2
Enhanced glutamate release during REM sleep in the rostromedial medulla as measured by in vivo microdialysis.通过体内微透析测量，快速眼动睡眠期间延髓嘴内侧谷氨酸释放增强。
Brain Res. 1998 Jan 5;780(1):178-81.
3
Enhanced glutamate release during REM sleep in the rostromedial medulla as measured by in vivo microdialysis.通过体内微透析测量，在延髓嘴内侧，快速眼动睡眠期间谷氨酸释放增强。
Brain Res. 1998 Jan 5;780(1):176-9.
4
REM sleep without atonia after lesions of the medial medulla.延髓内侧损伤后出现无张力性快速眼动睡眠。
Neurosci Lett. 1989 Mar 27;98(2):159-65. doi: 10.1016/0304-3940(89)90503-x.
5
Corticotropin-releasing factor mediated muscle atonia in pons and medulla.促肾上腺皮质激素释放因子介导脑桥和延髓的肌肉张力缺失。
Brain Res. 1992 Mar 13;575(1):63-8. doi: 10.1016/0006-8993(92)90423-7.
6
Medullary regions mediating atonia.介导肌张力缺失的延髓区域。
J Neurosci. 1988 Dec;8(12):4790-6. doi: 10.1523/JNEUROSCI.08-12-04790.1988.
7
Behavioral response and transmitter release during atonia elicited by medial medullary stimulation.延髓内侧刺激引起的弛缓期行为反应和递质释放。
J Neurophysiol. 2010 Oct;104(4):2024-33. doi: 10.1152/jn.00528.2010. Epub 2010 Jul 28.
8
Microdialysis measurement of cortical and hippocampal acetylcholine release during sleep-wake cycle in freely moving cats.自由活动猫睡眠-觉醒周期中皮质和海马乙酰胆碱释放的微透析测量
Brain Res. 1995 Feb 13;671(2):329-32. doi: 10.1016/0006-8993(94)01399-3.
9
Medullary circuitry regulating rapid eye movement sleep and motor atonia.调节快速眼动睡眠和运动性无张力的髓质神经回路。
J Neurosci. 2009 Jul 22;29(29):9361-9. doi: 10.1523/JNEUROSCI.0737-09.2009.
10
Pontine nitric oxide modulates acetylcholine release, rapid eye movement sleep generation, and respiratory rate.脑桥一氧化氮调节乙酰胆碱释放、快速眼动睡眠的产生以及呼吸频率。
J Neurosci. 1997 Jan 15;17(2):774-85. doi: 10.1523/JNEUROSCI.17-02-00774.1997.
引用本文的文献
1
REM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individuals.快速眼动睡眠与 aMCI 个体中胆碱能基底前脑的体积有关。
Alzheimers Res Ther. 2023 Sep 8;15(1):151. doi: 10.1186/s13195-023-01265-y.
2
A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies.一种用于体外和体内研究的基因编码荧光乙酰胆碱指示剂。
Nat Biotechnol. 2018 Sep;36(8):726-737. doi: 10.1038/nbt.4184. Epub 2018 Jul 9.
3
Cholinergic modulation of the parafacial respiratory group.面神经旁呼吸组的胆碱能调节
J Physiol. 2017 Feb 15;595(4):1377-1392. doi: 10.1113/JP273012. Epub 2016 Dec 11.
4
Anatomical Location of the Mesencephalic Locomotor Region and Its Possible Role in Locomotion, Posture, Cataplexy, and Parkinsonism.中脑运动区的解剖位置及其在运动、姿势、猝倒和帕金森病中的可能作用。
Front Neurol. 2015 Jun 24;6:140. doi: 10.3389/fneur.2015.00140. eCollection 2015.
5
REM sleep: a biological and psychological paradox.快速眼动睡眠：一个生物学和心理学上的悖论。
Sleep Med Rev. 2011 Jun;15(3):139-42. doi: 10.1016/j.smrv.2011.01.001. Epub 2011 Apr 8.
6
Behavioral response and transmitter release during atonia elicited by medial medullary stimulation.延髓内侧刺激引起的弛缓期行为反应和递质释放。
J Neurophysiol. 2010 Oct;104(4):2024-33. doi: 10.1152/jn.00528.2010. Epub 2010 Jul 28.
7
The lateral paragigantocellular nucleus modulates parasympathetic cardiac neurons: a mechanism for rapid eye movement sleep-dependent changes in heart rate.外侧巨细胞旁核调制副交感神经心神经元：快速眼动睡眠依赖的心率变化的一种机制。
J Neurophysiol. 2010 Aug;104(2):685-94. doi: 10.1152/jn.00228.2010. Epub 2010 May 19.
8
The neurobiology of sleep.睡眠的神经生物学
Semin Neurol. 2009 Sep;29(4):277-96. doi: 10.1055/s-0029-1237118. Epub 2009 Sep 9.
9
Unearthing the phylogenetic roots of sleep.探寻睡眠的系统发育根源。
Curr Biol. 2008 Aug 5;18(15):R670-R679. doi: 10.1016/j.cub.2008.06.033.
10
Neurotoxic lesions at the ventral mesopontine junction change sleep time and muscle activity during sleep: an animal model of motor disorders in sleep.腹侧脑桥中脑交界处的神经毒性损伤会改变睡眠时间和睡眠期间的肌肉活动：一种睡眠运动障碍的动物模型。
Neuroscience. 2008 Jun 23;154(2):431-43. doi: 10.1016/j.neuroscience.2008.03.085. Epub 2008 Apr 16.
本文引用的文献
1
An inhibitory mechanism in the bulbar reticular formation.延髓网状结构中的一种抑制机制。
J Neurophysiol. 1946 May;9:165-71. doi: 10.1152/jn.1946.9.3.165.
2
[Research on the neural structures and responsible mechanisms in different phases of physiological sleep].[生理睡眠不同阶段的神经结构及相关机制研究]
Arch Ital Biol. 1962;100:125-206.
3
Acetylcholine sensitivity of cat's medullary neurons.猫延髓神经元的乙酰胆碱敏感性
J Neurophysiol. 1963 Jul;26:581-97. doi: 10.1152/jn.1963.26.4.581.
4
The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat.通过胆碱乙酰转移酶免疫组织化学对猫的中枢胆碱能系统进行研究。
J Comp Neurol. 1981 Aug 1;200(2):151-201. doi: 10.1002/cne.902000202.
5
Inhibitory effects evoked through ventral reticulospinal pathways.通过腹侧网状脊髓通路引发的抑制作用。
Arch Ital Biol. 1968 May;106(2):124-40.
6
A microdialysis method allowing characterization of intercellular water space in humans.一种可用于表征人体细胞间水空间的微透析方法。
Am J Physiol. 1987 Aug;253(2 Pt 1):E228-31. doi: 10.1152/ajpendo.1987.253.2.E228.
7
The nuclei of origin of monoaminergic, peptidergic, and cholinergic afferents to the cat nucleus reticularis magnocellularis: a double-labeling study with cholera toxin as a retrograde tracer.猫巨细胞网状核单胺能、肽能及胆碱能传入纤维的起源核团：以霍乱毒素作为逆行示踪剂的双重标记研究
J Comp Neurol. 1988 Nov 1;277(1):1-20. doi: 10.1002/cne.902770102.
8
Medullary regions mediating atonia.介导肌张力缺失的延髓区域。
J Neurosci. 1988 Dec;8(12):4790-6. doi: 10.1523/JNEUROSCI.08-12-04790.1988.
9
Distribution of acetylcholine and catecholamine neurons in the cat brainstem: a choline acetyltransferase and tyrosine hydroxylase immunohistochemical study.猫脑干中乙酰胆碱能和儿茶酚胺能神经元的分布：胆碱乙酰转移酶和酪氨酸羟化酶免疫组织化学研究
J Comp Neurol. 1987 Jul 1;261(1):15-32. doi: 10.1002/cne.902610103.
10
Unitary characteristics of presumptive cholinergic tegmental neurons during the sleep-waking cycle in freely moving cats.自由活动猫睡眠-觉醒周期中假定胆碱能被盖神经元的单一特征
Exp Brain Res. 1989;76(3):519-29. doi: 10.1007/BF00248908.
Zotero 插件