Collier A, Leach J P, McLellan A, Jardine A, Morton J J, Small M
Diabetic Unit, Gart-Navel General Hospital, Glasgow, UK.
Diabetes Care. 1992 Aug;15(8):1038-40. doi: 10.2337/diacare.15.8.1038.
To determine whether plasma endothelin, a potent vasoconstrictor and growth factor for vascular smooth muscle, is elevated in microalbuminuric insulin-dependent diabetes mellitus patients.
Plasma endothelinlike immunoreactivity was measured by radioimmunoassay in 15 microalbuminuric diabetic patients, 12 normoalbuminuric diabetic patients, and 12 control subjects.
The mean levels of plasma endothelinlike immunoreactivity were raised in the normoalbuminuric patients (8.4 pM [range 4.8-12.7 pM]; P less than 0.01) and the microalbuminuric patients (10.2 pM [range 5.6-31.1 pM]; P less than 0.001) compared with control subjects (6.1 pM [range 4.5-7.6 pM]). Plasma endothelinlike immunoreactivity was also higher in the microalbuminuric patients compared with the normoalbuminuric patients (P less than 0.05).
The increase in plasma endothelinlike immunoreactivity further confirms endothelial dysfunction in diabetes and this increase in plasma endothelin may contribute to the vascular disease prevalent in diabetes.
确定血浆内皮素（一种强效血管收缩剂及血管平滑肌生长因子）在微量白蛋白尿的胰岛素依赖型糖尿病患者中是否升高。
采用放射免疫分析法测定了15例微量白蛋白尿糖尿病患者、12例正常白蛋白尿糖尿病患者及12例对照者的血浆内皮素样免疫活性。
与对照者（6.1皮摩尔[范围4.5 - 7.6皮摩尔]）相比，正常白蛋白尿患者（8.4皮摩尔[范围4.8 - 12.7皮摩尔]；P<0.01）及微量白蛋白尿患者（10.2皮摩尔[范围5.6 - 31.1皮摩尔]；P<0.001）的血浆内皮素样免疫活性平均水平升高。与正常白蛋白尿患者相比，微量白蛋白尿患者的血浆内皮素样免疫活性也更高（P<0.05）。
血浆内皮素样免疫活性升高进一步证实了糖尿病患者存在内皮功能障碍，且血浆内皮素的这种升高可能促成了糖尿病中普遍存在的血管疾病。
