Division of Pediatric Endocrinology, Department of Pediatrics, Riley Hospital for Children at Indiana University Health, Indianapolis, IN.
Division of Pediatric Endocrinology, Department of Pediatrics, Riley Hospital for Children at Indiana University Health, Indianapolis, IN.
J Pediatr. 2021 Dec;239:228-230. doi: 10.1016/j.jpeds.2021.08.087. Epub 2021 Sep 4.
There is inconsistency in the amount of oral desmopressin that children with central diabetes insipidus require. We investigated whether clinical characteristics influenced desmopressin dose requirements in 100 children with central diabetes insipidus. Extremely large doses were associated with acquired etiology (P = .04), greater body mass index z score, intact thirst, and additional pituitary hormone deficiencies (P < .001).
儿童中枢性尿崩症所需的口服去氨加压素剂量存在差异。我们研究了 100 例中枢性尿崩症患儿的临床特征是否影响去氨加压素剂量需求。超大剂量与获得性病因（P=.04）、更大的体重指数 z 评分、完整的渴感和其他垂体激素缺乏（P<.001）有关。
