Mavromichalis I, Zaramboukas T, Richman P I, Slavin G
Second Paediatric Department, Aristotelian University of Thessaloniki, AHEPA General Hospital, Greece.
Eur J Pediatr. 1992 Aug;151(8):560-3. doi: 10.1007/BF01957720.
A consecutive series of 71 children (mean age 8.6 years) with recurrent abdominal pain underwent endoscopic oesophageal, gastric and duodenal biopsy in order to determine whether the pain was of gastro-intestinal origin. Of these 71 children, 27 (38%) showed oesophagitis, 14 (20%) cardiac gastritis, 29 (41%) body gastritis, 38 (54%) antral gastritis, and 29 (41%) duodenitis. Thus, 66 of the 71 children studied had an inflammatory lesion explaining their complaints. One of the patients had a gastric ulcer. Helicobacter pylori colonisation was found in 5 of the children: One had H. pylori associated antral and body gastritis and 4 H. pylori associated antral gastritis only. Body gastritis without H. pylori was present in three of these four children. Our data do not support the widespread assumption that recurrent abdominal pain for which no medical cause can be found, is psychogenic; neither do they establish an association between H. pylori antral gastritis and recurrent abdominal pain. However, our data provide strong evidence that there is a gastro-intestinal origin of these patients' complaints.
对71名复发性腹痛儿童（平均年龄8.6岁）进行了连续研究，这些儿童接受了食管、胃和十二指肠内镜活检，以确定疼痛是否源于胃肠道。在这71名儿童中，27名（38%）患有食管炎，14名（20%）患有贲门胃炎，29名（41%）患有胃体胃炎，38名（54%）患有胃窦炎，29名（41%）患有十二指肠炎。因此，在研究的71名儿童中，有66名存在炎症性病变可以解释他们的症状。其中一名患者患有胃溃疡。在5名儿童中发现了幽门螺杆菌定植：1名患有幽门螺杆菌相关性胃窦和胃体胃炎，4名仅患有幽门螺杆菌相关性胃窦炎。这4名儿童中有3名存在无幽门螺杆菌的胃体胃炎。我们的数据不支持普遍认为的找不到医学原因的复发性腹痛是心因性的假设；也没有证实幽门螺杆菌相关性胃窦炎与复发性腹痛之间存在关联。然而，我们的数据提供了有力证据，证明这些患者的症状源于胃肠道。
