van der Meer S B, Forget P P, Arends J W
Department of Paediatrics, Academic Hospital, Maastricht, The Netherlands.
Arch Dis Child. 1990 Dec;65(12):1311-4. doi: 10.1136/adc.65.12.1311.
Thirty nine children with recurrent abdominal pain aged between 5.5 and 12 years, underwent endoscopic duodenal biopsy to find out if there were any duodenal inflammatory changes, and if there was a relationship between duodenal inflammation and intestinal permeability to 51Cr-EDTA. Duodenal inflammation was graded by the duodenitis scale of Whitehead et al (grade 0, 1, 2, and 3). In 13 out of 39 patients (33%) definite signs of inflammation were found (grade 2 and 3). Intestinal permeability to 51Cr-EDTA in patients with duodenitis (grade 1, 2, and 3) was significantly higher (4.42 (1.73)%) than in patients with normal (grade 0) duodenal biopsy appearances (3.3 (0.9)%). A significant association was found between duodenal inflammation and abnormal intestinal permeability. Our results give further evidence that there is an intestinal origin of these patients' complaints.
39名年龄在5.5至12岁之间的复发性腹痛儿童接受了十二指肠内镜活检，以确定是否存在十二指肠炎症变化，以及十二指肠炎症与肠道对51Cr - EDTA的通透性之间是否存在关联。十二指肠炎症根据Whitehead等人的十二指肠炎症量表进行分级（0级、1级、2级和3级）。在39名患者中的13名（33%）发现了明确的炎症迹象（2级和3级）。十二指肠炎症（1级、2级和3级）患者对51Cr - EDTA的肠道通透性（4.42（1.73）%）显著高于十二指肠活检外观正常（0级）的患者（3.3（0.9）%）。发现十二指肠炎症与肠道通透性异常之间存在显著关联。我们的结果进一步证明了这些患者的症状源于肠道。
