Cohn Melvin
The Salk Institute for Biological Studies, Conceptual Immunology Group, La Jolla, CA 92037-1099, USA.
Immunology. 2004 Apr;111(4):375-80. doi: 10.1111/j.0019-2805.2004.01830.x.
Given that recognition by the T-cell receptor (TCR) of allele-specific determinants on major histocompatibility complex (MHC)-encoded restricting elements (Rs) is germline encoded, whereas recognition of peptide (P) is somatically encoded, two combining site repertoires, anti-R and anti-P, are implied. As a consequence, the three pathways of T cells, positive selection, negative selection and activation, must be signalled by qualitatively distinct interactions engaging the TCR. These are spelled out as they provide an alternative to the current thinking that these pathways depend on affinity-based quantitatively distinguishable interactions.
鉴于T细胞受体（TCR）对主要组织相容性复合体（MHC）编码的限制元件（Rs）上等位基因特异性决定簇的识别是种系编码的，而对肽（P）的识别是体细胞编码的，这意味着存在两种结合位点库，即抗-R和抗-P。因此，T细胞的三种途径，阳性选择、阴性选择和激活，必须通过与TCR发生性质不同的相互作用来发出信号。之所以详细说明这些，是因为它们为目前认为这些途径依赖于基于亲和力的定量可区分相互作用的观点提供了一种替代。
