重新审视急性HIV：治疗与预防的新机遇
Acute HIV revisited: new opportunities for treatment and prevention.
作者信息
Pilcher Christopher D, Eron Joseph J, Galvin Shannon, Gay Cynthia, Cohen Myron S
机构信息
Department of Medicine, University of North Carolina at Chapel Hill, 27599-7215, USA.
出版信息
J Clin Invest. 2004 Apr;113(7):937-45. doi: 10.1172/JCI21540.
Abstract
Inability to recognize incident infection has traditionally limited both scientific and public health approaches to HIV disease. Recently, some laboratories have begun adding HIV nucleic acid amplification testing to HIV diagnostic testing algorithms so that acute (antibody-negative) HIV infections can be routinely detected within the first 1-3 weeks of exposure. In this review article, we will highlight critical opportunities for HIV treatment and prevention that are presented by these diagnostic strategies.
摘要
传统上，无法识别新发感染限制了针对HIV疾病的科学和公共卫生方法。最近，一些实验室已开始在HIV诊断检测算法中增加HIV核酸扩增检测，以便在接触后的头1至3周内常规检测出急性（抗体阴性）HIV感染。在这篇综述文章中，我们将重点介绍这些诊断策略所带来的HIV治疗和预防的关键机遇。
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1
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J Infect Dis. 2004 May 15;189(10):1785-92. doi: 10.1086/386333. Epub 2004 Apr 28.
2
Frequent detection of acute primary HIV infection in men in Malawi.在马拉维男性中频繁检测到急性原发性艾滋病毒感染。
AIDS. 2004 Feb 20;18(3):517-24. doi: 10.1097/00002030-200402200-00019.
3
The role of sexually transmitted diseases in HIV transmission.性传播疾病在艾滋病毒传播中的作用。
Nat Rev Microbiol. 2004 Jan;2(1):33-42. doi: 10.1038/nrmicro794.
4
Correlation between env V1/V2 region diversification and neutralizing antibodies during primary infection by simian immunodeficiency virus sm in rhesus macaques.恒河猴感染猿猴免疫缺陷病毒sm原发性感染期间env V1/V2区域多样性与中和抗体之间的相关性。
J Virol. 2004 Apr;78(7):3561-71. doi: 10.1128/jvi.78.7.3561-3571.2004.
5
Acute human immunodeficiency virus infection in patients presenting to an urban urgent care center.
Clin Infect Dis. 2003 Dec 15;37(12):1699-704. doi: 10.1086/379772. Epub 2003 Nov 17.
6
Partner counseling and referral services to identify persons with undiagnosed HIV--North Carolina, 2001.2001年北卡罗来纳州为识别未确诊的艾滋病毒感染者而提供的性伴咨询和转介服务
MMWR Morb Mortal Wkly Rep. 2003 Dec 5;52(48):1181-4.
7
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J Infect Dis. 2003 Nov 15;188(10):1426-32. doi: 10.1086/379251. Epub 2003 Oct 27.
8
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Arch Intern Med. 2003 Sep 22;163(17):2097-100. doi: 10.1001/archinte.163.17.2097.
9
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10
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