Basu J, Mikhail M S, Palan P R, Thysen B, Bloch E, Romney S L
Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10461.
Gynecol Obstet Invest. 1992;33(4):224-7. doi: 10.1159/000294888.
The simultaneous effects of cigarette smoking and oral contraceptives on serum estradiol and progesterone levels were investigated in 114 premenopausal women. Serum 17 beta-estradiol and progesterone levels were measured by radioimmunoassay. In smokers, estradiol and progesterone levels were significantly lower (p less than 0.025). In smokers using oral contraceptives, estradiol and progesterone levels were the lowest (p less than 0.001 and p less than 0.01, respectively). The findings suggest that smoking and oral contraceptives independently lower serum estradiol and progesterone concentrations in premenopausal women and that the effects may be additive.
在114名绝经前女性中研究了吸烟与口服避孕药对血清雌二醇和孕酮水平的联合影响。采用放射免疫分析法测定血清17β-雌二醇和孕酮水平。吸烟者的雌二醇和孕酮水平显著较低（p<0.025）。在使用口服避孕药的吸烟者中，雌二醇和孕酮水平最低（分别为p<0.001和p<0.01）。这些发现表明，吸烟和口服避孕药各自都会降低绝经前女性的血清雌二醇和孕酮浓度，且这些影响可能具有叠加性。
