Donnez J, Langerock S, Thomas K
Obstet Gynecol. 1982 Jun;59(6):687-92.
Data on the volume of peritoneal fluid and the concentrations of estradiol (17 beta-estradiol) and progesterone during the normal menstrual cycle of 158 women are reported and compared with data obtained from women with anovulatory cycles (N = 16), women using hormonal contraceptives (N = 40), and postmenopausal women (N = 6). During the menstrual cycle, the volume of peritoneal fluid increased significantly after ovulation and remained high for at least 10 days, whereas only small quantities were found in women taking oral contraceptives and in women after menopause. During the follicular phase, estradiol and progesterone concentrations in peritoneal fluid were in the same range as the levels in serum. After ovulation (days 14 to 16), the ratios of the hormonal levels in peritoneal fluid and serum, respectively, were 10 for estradiol and 63 for progesterone. The concentrations of estradiol and progesterone in peritoneal fluid were much higher than in serum for at least 1 week after ovulation. The comparison between the different groups suggests that variations in peritoneal fluid during the menstrual cycle are directly related to cyclic ovarian activity. This particular hormonal environment of the ovocyte in vivo has to be considered in future studies on female infertility that focus on maturation and fertilization in vitro.
报告了158名女性正常月经周期中腹腔液体积以及雌二醇（17β - 雌二醇）和孕酮浓度的数据，并与无排卵周期女性（N = 16）、使用激素避孕药的女性（N = 40）和绝经后女性（N = 6）获得的数据进行了比较。在月经周期中，排卵后腹腔液体积显著增加，并至少持续10天保持高位，而在服用口服避孕药的女性和绝经后女性中仅发现少量腹腔液。在卵泡期，腹腔液中雌二醇和孕酮浓度与血清中的水平处于同一范围。排卵后（第14至16天），腹腔液与血清中激素水平的比值，雌二醇分别为10，孕酮为63。排卵后至少1周内，腹腔液中雌二醇和孕酮的浓度远高于血清中的浓度。不同组之间的比较表明，月经周期中腹腔液的变化与卵巢的周期性活动直接相关。在未来关于女性不孕症的研究中，如果关注体外成熟和受精，必须考虑卵母细胞在体内这种特殊的激素环境。
