Muderawan I Wayan, Ong Teng-Teng, Ng Siu-Choon
Division of Chemical and Biomolecular Engineering, Nanyang Technological University, Singapore.
J Sep Sci. 2006 Aug;29(12):1849-71. doi: 10.1002/jssc.200500491.
Several structurally well-defined perfunctionalised cyclodextrin chiral stationary phases (CD CSPs) for high performance liquid chromatography have been successfully prepared by immobilisation of perfunctionalised cyclodextrins on silica through urea linkage(s) using the Staudinger reaction. These CSPs show high chiral recognition efficiency and are utilised in the resolution of various types of racemic compounds. This paper reviews the development of sixteen perfunctionalised cyclodextrin-based CSPs, their preparation, and their application to enantioseparation of seventy-seven racemic compounds under a range of separation conditions.
通过使用施陶丁格反应，经脲键将全功能化环糊精固定在硅胶上，成功制备了几种结构明确的用于高效液相色谱的全功能化环糊精手性固定相（CD CSPs）。这些CSPs表现出高的手性识别效率，并用于各种外消旋化合物的拆分。本文综述了十六种基于全功能化环糊精的CSPs的发展、它们的制备以及在一系列分离条件下对77种外消旋化合物进行对映体拆分的应用。
