Vara-Thorbeck R, Guerrero J A, Ruiz-Requena M E, Capitán J, Rodriguez M, Rosell J, Mekinassi K, Maldonado M, Martin R
Department of Surgery, University of Granada, Spain.
Hepatogastroenterology. 1992 Jun;39(3):270-2.
The purpose of the present study was to determine whether the administration of a biosynthetic human growth hormone was capable of enhancing the efficacy of total parenteral nutrition. Patients (n = 38) who had undergone major gastrointestinal surgery were randomly divided into two groups. Group I (n = 20) treated only with PN, and Group II (n = 18) treated as in Group I plus human growth hormone (4 IU daily). Our study shows that the administration of human growth hormone produces a statistically significant increase in serum levels of growth hormone, somatomedin-C, transferrin, albumin and total proteins. It also causes a positive nitrogen balance from the first 24 hours onward. These findings suggest that the administration of human growth hormone produces an increase in protein synthesis, perhaps through somatomedin-C as mediator.
本研究的目的是确定给予生物合成人生长激素是否能够增强全胃肠外营养的效果。接受大型胃肠道手术的患者（n = 38）被随机分为两组。第一组（n = 20）仅接受肠外营养治疗，第二组（n = 18）在接受与第一组相同治疗的基础上加用人生长激素（每日4 IU）。我们的研究表明，给予人生长激素可使生长激素、胰岛素样生长因子-C、转铁蛋白、白蛋白和总蛋白的血清水平出现具有统计学意义的升高。从术后24小时起还可导致正氮平衡。这些发现提示，给予人生长激素可能通过胰岛素样生长因子-C作为介质来促进蛋白质合成。
