Guerrero J A, Capitán J M, Rosell J, Ruiz M E, García E, García-Carriazo M, Maldonado M J, Vara Thorbeck R
Cátedra de Patología y Clínica Quirúrgica, Hospital Universitario, Granada.
Rev Esp Enferm Dig. 1992 Jun;81(6):379-82.
The purpose of the present study was to determine if the administration of a biosynthetic human growth hormone (bGH) was able to enhance the efficacy of total parenteral nutrition (PN). Patients (n = 38) who had undergone major gastrointestinal surgery were randomly divided in two groups. Group I (n = 20) treated only with PN and Group II (n = 18) treated as in Group I plus bGH (4 UI/daily). Our study shows that the administration of bGH produces a significant increase in serum levels of growth hormone and Somatomedin-C. It also caused a positive nitrogen balance from the first 24 hours on (p less than 0.01). In Group II on day 12 after operation a statistically significant increase in transferrin (p less than 0.05), albumin (p less than 0.01) and total proteins (p less than 0.02) was observed. Our study suggest that the administration of bGH produces, perhaps through Somatomedin-C as mediator, an increase in protein synthesis.
本研究的目的是确定给予生物合成人生长激素（bGH）是否能够提高全胃肠外营养（PN）的疗效。接受大型胃肠道手术的患者（n = 38）被随机分为两组。第一组（n = 20）仅接受PN治疗，第二组（n = 18）的治疗方法与第一组相同，但加用bGH（4 UI/每日）。我们的研究表明，给予bGH可使生长激素和生长调节素-C的血清水平显著升高。从最初的24小时起还导致了正氮平衡（p < 0.01）。在第二组中，术后第12天观察到转铁蛋白（p < 0.05）、白蛋白（p < 0.01）和总蛋白（p < 0.02）有统计学意义的增加。我们的研究表明，给予bGH可能通过生长调节素-C作为介质，使蛋白质合成增加。
