Mjaaland M, Unneberg K, Hotvedt R, Revhaug A
Department of Surgery, Tromsø University Hospital, Norway.
Eur J Surg. 1991 Jan;157(1):21-7.
Nineteen patients undergoing elective gastrointestinal surgery were randomised to receive recombination human growth hormone (n = 9) or placebo (n = 10) for the first five postoperative days. All received epidural analgesia and total parenteral nutrition during the same period (energy supply 125% of basal metabolic rate, mean nitrogen (+/- SEM) 5.7 (+/- 0.1) g/m2). Nitrogen and potassium retention was induced in the growth hormone group compared with the placebo group (cumulative nitrogen balance 4.1 (+/- 1.1) g/m2 in the growth hormone group and -3.1 (+/- 1.8) g/m2 in the placebo group, p less than 0.01; cumulative potassium balance 80.8 (+/- 4.7) mmol/m2 in the growth hormone group and 43.1 (+/- 11.4) mmol/m2 in the placebo group, p less than 0.01). In the growth hormone group, serum glucose concentrations increased each evening and mean serum albumin concentrations were reduced throughout the period; the morning pulse rates were decreased, and the patients gained weight compared with the placebo group.
19例接受择期胃肠手术的患者被随机分为两组，术后前5天分别接受重组人生长激素（n = 9）或安慰剂（n = 10）治疗。在此期间，所有患者均接受硬膜外镇痛和全胃肠外营养（能量供应为基础代谢率的125%，平均氮摄入量（±标准误）为5.7（±0.1）g/m²）。与安慰剂组相比，生长激素组出现氮和钾潴留（生长激素组累积氮平衡为4.1（±1.1）g/m²，安慰剂组为-3.1（±1.8）g/m²，p<0.01；生长激素组累积钾平衡为80.8（±4.7）mmol/m²，安慰剂组为43.1（±11.4）mmol/m²，p<0.01）。在生长激素组中，血清葡萄糖浓度每晚升高，整个期间平均血清白蛋白浓度降低；与安慰剂组相比，早晨脉搏率降低，患者体重增加。
