Chakrabarti Kushal, Pachter Lior
Department of Computer Science, University of California, Berkeley, Berkeley, California 94720, USA.
Genome Res. 2004 Apr;14(4):716-20. doi: 10.1101/gr.1957004.
We introduce a novel genome browser application, the K-BROWSER, that allows intuitive visualization of biological information across an arbitrary number of multiply aligned genomes. In particular, the K-BROWSER simultaneously displays an arbitrary number of genomes both through overlaid annotations and predictions that describe their respective characteristics, and through the multiple alignment that describes their global relationship to one another. The browsing environment has been designed to allow users seamless access to information available in every genome and, furthermore, to allow easy navigation within and between genomes. As of the date of publication, the K-BROWSER has been set up on the human, mouse, and rat genomes.
我们推出了一款新颖的基因组浏览器应用程序——K-BROWSER，它能够直观地呈现跨越任意数量多重比对基因组的生物信息。具体而言，K-BROWSER通过描述各自特征的叠加注释和预测，以及描述它们彼此之间全局关系的多重比对，同时展示任意数量的基因组。浏览环境的设计旨在让用户能够无缝访问每个基因组中的可用信息，此外，还能在基因组内部以及不同基因组之间轻松导航。截至发布之日，K-BROWSER已在人类、小鼠和大鼠基因组上搭建完成。
