Weiss Bernard, Amler Sherlita, Amler Robert W
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
Pediatrics. 2004 Apr;113(4 Suppl):1030-6.
Pesticides are a broad group of heterogeneous chemicals that have a significant public health benefit by increasing food production productivity and decreasing food-borne and vector-borne diseases. However, depending on the agent and the exposure, they may pose health risks. Because of their behavior, acute accidental toxic exposures occur more commonly in children. Because of the dietary habits and greater intake of foods per kilogram in children and because some infants are breastfed, there is also concern about the effects on them of low-level environmental exposures. In the absence of direct conclusive evidence, consistent and relevant observations have led some investigators to infer that chronic low-dose exposure to certain pesticides might pose a potential hazard to the health and development of infants and children. Other investigators have concluded that such inferences can be neither supported nor refuted at the present time. The pediatrician has a role to play in recognizing the symptoms of acute exposure and to be able to provide appropriate treatment. It is essential to study whether there are subtle neurologic effects that may result from low-level pesticide exposures in individual patients.
农药是一大类性质各异的化学品,通过提高粮食生产效率以及减少食源性和病媒传播疾病,对公众健康有重大益处。然而,根据具体的药剂和接触情况,它们可能会带来健康风险。由于其特性,急性意外中毒暴露在儿童中更为常见。由于儿童的饮食习惯以及每公斤体重摄入食物量较大,并且一些婴儿是母乳喂养,因此人们也担心低水平环境暴露对他们的影响。在缺乏直接确凿证据的情况下,一些研究者根据一致且相关的观察结果推断,长期低剂量接触某些农药可能对婴幼儿的健康和发育构成潜在危害。其他研究者则得出结论,目前这些推断既无法得到支持,也无法被反驳。儿科医生在识别急性接触症状并能够提供适当治疗方面发挥着作用。研究个体患者因低水平农药暴露是否会产生细微的神经学影响至关重要。