James T J, Sharma S P, Gupta S K, Patro I K
Department of Zoology, Kurukshetra University, India.
Indian J Exp Biol. 1992 Jun;30(6):470-3.
This paper deals with some deleterious effects of protein malnourishment in rat cerebellum. Severe protein deprivation enhanced the formation of 'dark' cells in white rats. It is postulated that abnormal changes in the neuronal contents induced by nutritional stress play a vital role in the formation of the 'dark' cells through an intermediary stage, 'semi-dark' cells. Centrophenoxine a lipofuscinolytic agent, however, seems to interfere with the process of formation of 'dark' cells and/or helps reconversion of the 'dark' cells into the normal or 'light' type Purkinje cells.
本文探讨了蛋白质营养不良对大鼠小脑的一些有害影响。严重的蛋白质缺乏会增加白鼠中“暗”细胞的形成。据推测，营养应激引起的神经元内容物异常变化通过一个中间阶段“半暗”细胞，在“暗”细胞的形成中起着至关重要的作用。然而，中枢酚嗪，一种脂褐素溶解剂，似乎会干扰“暗”细胞的形成过程，和/或有助于将“暗”细胞重新转化为正常或“亮”型浦肯野细胞。
