Filhol Odile, Martiel Jean-Louis, Cochet Claude
INSERM EMI 104, Département Réponse et Dynamique Cellulaire, CEA, 38054 Grenoble, France.
EMBO Rep. 2004 Apr;5(4):351-5. doi: 10.1038/sj.embor.7400115.
Protein kinase CK2 (formerly known as casein kinase II) has been viewed traditionally as a stable heterotetrameric complex, but new analytical techniques are bringing a different picture into focus. The transient nature of this complex has been highlighted by the elucidation of its structure. Furthermore, analysis of the spatiotemporal organization of individual CK2 subunits in living cells has shown that they are dynamic and that they integrate into different multimolecular assemblies. These new studies give an additional dimension to the challenge of determining the cellular regulation of this protein kinase.
蛋白激酶CK2(以前称为酪蛋白激酶II)传统上被视为一种稳定的异源四聚体复合物,但新的分析技术正在使一种不同的情况成为焦点。该复合物的瞬时性质已通过其结构的阐明而得到凸显。此外,对活细胞中单个CK2亚基的时空组织分析表明,它们是动态的,并且它们整合到不同的多分子组装体中。这些新研究为确定这种蛋白激酶的细胞调节这一挑战增添了新的维度。