韩国小学生脊髓灰质炎病毒抗体血清流行率研究。
A seroprevalence study of poliovirus antibody among primary schoolchildren in Korea.
作者信息
Jee Y M, Cheon D S, Kim K S, Lee S H, Yoon J D, Lee S W, Go U, Yang B K, Ki M R, Choi B Y, Cho H W
机构信息
Laboratory of Enteroviruses, Department of Virology, National Institute of Health, Seoul, Korea.
出版信息
Epidemiol Infect. 2004 Apr;132(2):351-5. doi: 10.1017/s0950268803001663.
We aimed to determine the seroprevalence of poliovirus antibody in Korea by using the cell culture neutralization method recommended by the WHO. A total of 500 sera collected from children at eight primary schools in Kyunggi province were used for this study. We found that 82.2% of children were positive for all three types of poliovirus and antibody-positive rates for types I, II and III were 94.4, 96.6 and 86.8% respectively, indicating that seropositive rates for types I and II were considerably higher than for type III (P<0.0001). This result implies that the type III component of the oral polio vaccine should be evaluated further. Although a greater number of children, including young infants, need to be tested for seroprevalence, this study still provides us with valuable information on the effectiveness of vaccination against polioviruses in Korea.
我们旨在通过使用世界卫生组织推荐的细胞培养中和法来确定韩国脊髓灰质炎病毒抗体的血清流行率。本研究使用了从京畿道八所小学的儿童中收集的500份血清。我们发现，82.2%的儿童三种脊髓灰质炎病毒抗体均呈阳性，I型、II型和III型的抗体阳性率分别为94.4%、96.6%和86.8%，这表明I型和II型的血清阳性率显著高于III型（P<0.0001）。这一结果意味着口服脊髓灰质炎疫苗的III型成分应进一步评估。尽管需要对更多儿童（包括幼儿）进行血清流行率检测，但本研究仍为我们提供了关于韩国脊髓灰质炎病毒疫苗接种效果的宝贵信息。
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