Ananthan R, Latha M, Ramkumar K M, Pari L, Baskar C, Narmatha Bai V
Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India.
Exp Diabesity Res. 2003 Jul-Sep;4(3):183-9. doi: 10.1155/EDR.2003.183.
The effect of Gymnema montanum leaves on alloxan-induced hyperlipidemia was studied in male Wistar rats. Ethanolic extract of G. montanum leaves was administered orally and different doses of the extract on blood glucose, serum and tissue lipids, hexokinase, glucose-6-phosphatase, thiobarbituric acid-reactive substances (TBARS), hydroperoxides, and glutathione in alloxan-induced diabetic rats were studied. G. montanum leaf extract (GLEt) at doses of 50, 100, 200 mg/kg body weight for 3 weeks suppressed the elevated blood glucose and lipid levels in diabetic rats. GLEt at 200 mg/kg body weight was found to be comparable to glibenclamide, a reference drug. These data indicate that G. montanum represents an effective antihyperglycemic and antihyperlipidemic adjunct for the treatment of diabetes and a potential source of discovery of new orally active agent for future therapy.
研究了蒙山药叶对四氧嘧啶诱导的雄性Wistar大鼠高脂血症的影响。口服给予蒙山药叶乙醇提取物，并研究了不同剂量提取物对四氧嘧啶诱导的糖尿病大鼠血糖、血清和组织脂质、己糖激酶、葡萄糖-6-磷酸酶、硫代巴比妥酸反应性物质（TBARS）、氢过氧化物和谷胱甘肽的影响。剂量为50、100、200mg/kg体重的蒙山药叶提取物（GLEt）连续3周可抑制糖尿病大鼠升高的血糖和脂质水平。发现体重200mg/kg的GLEt与参考药物格列本脲相当。这些数据表明，蒙山药是治疗糖尿病的有效降血糖和降血脂辅助药物，也是未来治疗中发现新型口服活性药物的潜在来源。
