Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamilnadu, India.
Food Chem Toxicol. 2011 Dec;49(12):3390-4. doi: 10.1016/j.fct.2011.09.027. Epub 2011 Sep 29.
In the present study, the effect of alcoholic stem extract of Gymnema montanum (GMSt) on blood glucose, plasma insulin, and carbohydrate metabolic enzymes were studied in experimental diabetes. Diabetes mellitus was induced by a single intraperitoneal injection of STZ (60 mg/kg bw). Five days after STZ induction, diabetic rats received GMSt orally at the doses of 25, 50, 100 and 200mg/kg daily for 3 weeks. Graded doses of stem extract showed a significant reduction in blood glucose levels and improvement in plasma insulin levels. The effect was more pronounced in 100 and 200mg/kg than 50mg/kg. GMSt showed significant increase in hexokinase, Glucose-6-phosphate dehydrogenase and glycogen content in liver of diabetic rats while there was significant reduction in the levels of glucose-6-phosphatase and fructose-1,6-bisphosphatase. The present study clearly indicated significant antidiabetic effect with the stem extract of G. montanum and lends support for its traditional usage.
在本研究中，研究了匙羹藤（Gymnema montanum）茎提取物对实验性糖尿病的血糖、血浆胰岛素和碳水化合物代谢酶的影响。糖尿病是通过单次腹腔注射 STZ（60mg/kg bw）诱导的。STZ 诱导后 5 天，糖尿病大鼠每天口服给予 GMSt25、50、100 和 200mg/kg 剂量，持续 3 周。不同剂量的提取物均显著降低血糖水平，改善血浆胰岛素水平。100 和 200mg/kg 剂量的效果比 50mg/kg 更为明显。GMSt 显著增加了糖尿病大鼠肝脏中的己糖激酶、葡萄糖-6-磷酸脱氢酶和糖原含量，而葡萄糖-6-磷酸酶和果糖-1,6-二磷酸酶的水平则显著降低。本研究清楚地表明匙羹藤茎提取物具有显著的抗糖尿病作用，为其传统用途提供了支持。
