Khanzode Shruti S, Muddeshwar M G, Khanzode Suchet D, Dakhale Ganesh N
Government Medical College, Nagpur, India.
Free Radic Res. 2004 Jan;38(1):81-5. doi: 10.1080/01411590310001637066.
Oxidative stress resulting from an imbalance between pro-oxidants and anti-oxidants seems to play an important role in human breast carcinogenesis. There are conflicting reports regarding the tissue levels of malondialdehyde (MDA), ascorbic acid and superoxide dismutase (SOD) in breast cancer patients whereas few blood values have been reported. The present study was carried out to observe the changes in serum MDA, serum SOD and plasma ascorbic acid with the stage-wise progression of the disease. Serum MDA and serum SOD levels were found to be increased gradually from Stage I to Stage IV as compared to control group (p < 0.001). The maximum rise was in Stage IV patients. In contrast, mean plasma ascorbic acid levels were low in all stages compared to control group (p < 0.001). The decrease was more pronounced in Stage III and Stage IV. The study would be of immense help for establishing blood based biochemical marker in breast cancer patients.
由促氧化剂和抗氧化剂之间失衡导致的氧化应激似乎在人类乳腺癌发生过程中发挥重要作用。关于乳腺癌患者组织中丙二醛（MDA）、抗坏血酸和超氧化物歧化酶（SOD）水平的报道相互矛盾，而关于血液值的报道较少。本研究旨在观察随着疾病分期进展血清MDA、血清SOD和血浆抗坏血酸的变化。与对照组相比，血清MDA和血清SOD水平从I期到IV期逐渐升高（p < 0.001）。IV期患者升高幅度最大。相比之下，与对照组相比，各阶段的平均血浆抗坏血酸水平均较低（p < 0.001）。III期和IV期下降更为明显。该研究对于建立乳腺癌患者基于血液的生化标志物将有极大帮助。
