Department of Pharmaceutical Science, University of Perugia, 06100 Perugia, Italy.
Int J Mol Sci. 2020 Nov 9;21(21):8397. doi: 10.3390/ijms21218397.
The most frequent cancer in women is breast cancer, which is a major cause of death. Currently, there are many pharmacological therapies that have made possible the cure and resolution of this tumor. However, these therapies are accompanied by numerous collateral effects that influence the quality of life (QoL) of the patients to varying degrees. For this reason, attention is turning to the use of complementary medicine to improve QoL. In particular, there are increased trials of intravenous injection of vitamin C at high doses to enhance the antitumor activity of drugs and/or decrease their side effects. This review intends to underline the anticancer mechanisms of vitamin C that could explain its efficacy for treating breast cancer, and why the use of vitamin C at high doses could help patients with breast cancer to enhance the efficacy of pharmacological therapies and/or decrease their side effects.
女性最常见的癌症是乳腺癌，这也是主要的死亡原因之一。目前，有许多药理学疗法已经可以实现对这种肿瘤的治愈和消退。然而，这些疗法伴随着许多副作用，在不同程度上影响患者的生活质量（QoL）。出于这个原因，人们开始关注使用补充医学来提高 QoL。特别是，越来越多的试验采用高剂量静脉注射维生素 C，以增强药物的抗肿瘤活性和/或降低其副作用。本综述旨在强调维生素 C 的抗癌机制，这可以解释其治疗乳腺癌的疗效，以及为什么高剂量使用维生素 C 可以帮助乳腺癌患者增强药物治疗的疗效和/或降低其副作用。
