Bassong Thierry Renaud, Kenmogne Larissa Vanelle, Awounfack Charline Florence, Ndinteh Derek Tantoh, Njamen Dieudonné, Zingue Stéphane
Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaounde, Cameroon.
Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
Evid Based Complement Alternat Med. 2022 Apr 13;2022:9872788. doi: 10.1155/2022/9872788. eCollection 2022.
Breast cancer is a major threat worldwide. is widely consumed as beverage in sub-Saharan Africa for its anticancer potential. The present study therefore aimed at scientifically verifying its anticancer effect in rats. For this, 48 Wistar rats (∼55 days) were treated either with tamoxifen at 3.3 mg/kg BW (standard) or with a decoction of . (125, 250, and 500 mg/kg BW) or distilled water (vehicle). Breast cancer was induced by a single dose of 50 mg/kg of 7,12-dimethylbenz(a)anthracene (DMBA). At the end of the 21 weeks of treatment, the tumor incidence, tumor morphology, histopathology, as well as some biochemical parameters in the tumors were assessed. As a result, 86% of DMBA's rats developed mammary tumors. The . extract (125 and 250 mg/kg) reduced tumor incidence by 63% and 75%, respectively; inhibited tumor burden by 84.86% and 38.78%, respectively, and decreased tumor volume by more than 72% compared to the DMBA group. It also protected rats against DMBA-induced diffuse breast neoplasia, and the optimal effect was recorded at 125 mg/kg. Furthermore, it significantly increases the SOD activity and decreases the MDA level. In summary, has antibreast tumor and antioxidant properties in rats, which could justify its common use to treat cancer.
乳腺癌是全球范围内的重大威胁。在撒哈拉以南非洲，它作为一种饮料被广泛饮用，因其具有抗癌潜力。因此，本研究旨在科学验证其对大鼠的抗癌作用。为此，将48只Wistar大鼠（约55日龄）分别用3.3毫克/千克体重的他莫昔芬（标准药物）、[某种植物]的水煎剂（125、250和500毫克/千克体重）或蒸馏水（赋形剂）进行处理。通过单次给予50毫克/千克的7,12 - 二甲基苯并(a)蒽（DMBA）诱导乳腺癌。在治疗21周结束时，评估肿瘤发生率、肿瘤形态、组织病理学以及肿瘤中的一些生化参数。结果，86%的DMBA处理大鼠发生了乳腺肿瘤。[某种植物]提取物（125和250毫克/千克体重）分别使肿瘤发生率降低了63%和75%；分别使肿瘤负荷抑制了84.86%和38.78%，与DMBA组相比，肿瘤体积减少了72%以上。它还保护大鼠免受DMBA诱导的弥漫性乳腺肿瘤形成，在125毫克/千克体重时记录到最佳效果。此外，它显著提高了超氧化物歧化酶（SOD）活性并降低了丙二醛（MDA）水平。总之，[某种植物]在大鼠中具有抗乳腺肿瘤和抗氧化特性，这可以证明其常用于治疗癌症的合理性。
需注意，原文中部分植物名称缺失，以上译文是根据完整逻辑补充完整后的内容。
